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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A study compared treatment with cinacalcet versus treatment with placebo in subjects with known hyperparathyroidism. The primary outcome of the study was the proportion of study subjects with a mean intact parathyroid hormone level < 250 pg/mL. Among the cinacalcet group (n = 371), 43% of subjects achieved the primary outcome; among the placebo group (n =
370), 5% achieved the primary outcome (p<0.05).
Which of the following is the number needed to treat (NNT)?

A) 3
B) 8
C) 14
D) 1

2. A patient with a nasogastric output of 8 L daily and respirations of 10 bpm has the following - laboratory values:

This clinical information is most consistent with which of the following?

A) Compensated metabolic alkalosis
B) Compensated respiratory alkalosis
C) Uncompensated respiratory alkalosis
D) Uncompensated metabolic alkalosis

3. A MEDLINE search fails to retrieve a clinical trial known by the searcher to have been published in a recently established open-access medical journal. This failure has most likely occurred because of which of the following?

A) The time that the journal has been available does not meet criteria for indexing.
B) MEDLINE selectively indexes articles of the highest scientific merit.
C) MEDLINE does not index open-access journals.
D) The searcher limited the search to "humans" and "English language."

4. For a 34-year-old Woman with a history of ethanol abuse, cirrhosis, ascites, and jaundice, which of the following is the most important factor predisposing her to hepatorenal syndrome?

A) Volume depletion
B) Hypokalemia
C) Hypocalcaemia
D) Metabolic acidosis

5. A pharmacotherapy specialist is the anticoagulation clinic manager at a for-profit institution.
One of the internal medicine physicians in this institution is interested in submitting a research grant application to the National Institutes of Health (NIH) to study the effectiveness of low- intensity warfarin therapy on prevention of recurrent venous thromboembolism in patients.
This was the subject of the PREVENT trial.
With regard to the grant application, the pharmacotherapy specialist should inform the physician about which of the following restrictions?

A) The NIH provides grants only to nonprofit organizations.
B) The NIH funds only studies involving drugs that have not yet been FDA-approved.
C) NIH-funded research can take place only on the campus.
D) The NIH funds only novel research.

Solutions: